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Use of ALK TKIs is effective for treatment of patients with ALK+ NSCLC and CNS involvement, and evidence supports alectinib, brigatinib or ceritinib in this setting as first-line t_Apr 10, 2024 · Platinum-based chemotherapy is the recommended adjuvant treatment for patients with resectable, ALK-positive non–small-cell lung cancer (NSCLC). Data on the effic#Currently, six ALK-target agents have been approved to treat advanced ALK+ NSCLC, including crizotinib, alectinib, ceritinib, ensartinib, brigatinib, and lorlatinib. These targeted!May 8, 2024 · Alectinib targets cancer cells that have specific changes, called rearrangements, in the ALK gene. The drug has been shown to increase how long people with ALK-posit_Nov 17, 2025 · Key Takeaways Neladalkib shows a 31% ORR in advanced ALK-positive NSCLC, with durable responses in 64% and 53% at 12 and 18 months, respectively. The drug …|Nov 20, 2025 · Neladalkib shows promising efficacy in advanced ALK+ NSCLC, offering durable responses and manageable safety, potentially transforming treatment options.+On April 18, 2024, the Food and Drug Administration approved alectinib (Alecensa, Genentech, Inc.) for adjuvant treatment following tumor resection in patients with anaplastic lymp