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Deeper With Trial
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We report results from a randomized phase 2 DEEPER trial (UMIN000018217, jRCTs061180022) to test the superiority of modified (m)-FOLFOXIRI plus weekly cetuximab over bevacizumab in patients with,Conclusions: The final survival analysis of the DEEPER trial demonstrated favorable PFS and OS with m-FOLFOXIRI plus cet in pts with RAS/BRAF wild-type and left-sided mCRC. The m-FOLFOXIRI plus cet regimen may be a good option for initial therapy, offering longer survival times in pts with extra-hepatic metastases.~The DEEPER trial (JACCRO CC-13) was designed to test the superiority of m-FOLFOXIRI +cetuximab over m-FOLFOXIRI+ bevacizumab, which is one of standard chemotherapy regimens, in patients with/A type of intervention model describing a clinical trial in which two or more groups of participants receive different interventions. For example, a two-arm parallel assignment involves two groups of participants.@The randomized phase II study of FOLFOXIRI plus cetuximab versus FOLFOXIRI plus bevacizumab as the first-line treatment in metastatic colorectal cancer with RAS wild-type tumors: The DEEPER trial (JACCRO CC-13).!A post-hoc sub-group analysis was performed according to metastasis status to evaluate the resection rate and survival time in RAS / BRAF wild-type (wt) and left-sided pts who were enrolled into the DEEPER trial (JACCRO CC-13) NCT02515734 comparing m-FOLFOXIRI plus cetuximab (Cet) and Bev as initial therapy for RAS wt mCRC pts.%Initial treatment with cetuximab yields better outcomes than bevacizumab when combined with mFOLFOXIRI in select patients with mCRC, according to an exploratory analysis of more mature data from the phase 2 DEEPER trial (Abstract 17).
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We report results from a randomized phase 2 DEEPER trial (UMIN000018217, jRCTs061180022) to test the superiority of modified (m)-FOLFOXIRI plus weekly cetuximab over bevacizumab in patients with,Conclusions: The final survival analysis of the DEEPER trial demonstrated favorable PFS and OS with m-FOLFOXIRI plus cet in pts with RAS/BRAF wild-type and left-sided mCRC. The m-FOLFOXIRI plus cet regimen may be a good option for initial therapy, offering longer survival times in pts with extra-hepatic metastases.~The DEEPER trial (JACCRO CC-13) was designed to test the superiority of m-FOLFOXIRI +cetuximab over m-FOLFOXIRI+ bevacizumab, which is one of standard chemotherapy regimens, in patients with/A type of intervention model describing a clinical trial in which two or more groups of participants receive different interventions. For example, a two-arm parallel assignment involves two groups of participants.@The randomized phase II study of FOLFOXIRI plus cetuximab versus FOLFOXIRI plus bevacizumab as the first-line treatment in metastatic colorectal cancer with RAS wild-type tumors: The DEEPER trial (JACCRO CC-13).!A post-hoc sub-group analysis was performed according to metastasis status to evaluate the resection rate and survival time in RAS / BRAF wild-type (wt) and left-sided pts who were enrolled into the DEEPER trial (JACCRO CC-13) NCT02515734 comparing m-FOLFOXIRI plus cetuximab (Cet) and Bev as initial therapy for RAS wt mCRC pts.%Initial treatment with cetuximab yields better outcomes than bevacizumab when combined with mFOLFOXIRI in select patients with mCRC, according to an exploratory analysis of more mature data from the phase 2 DEEPER trial (Abstract 17).